Vaccine, pertussis: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Intramuscular
Active immunisation against pertussis

Adult: 11-64 yr: As combination product with diphtheria and tetanus toxoids: 0.5 ml as a single dose, preferably into the deltoid muscles. Ensure that 5 yr should have elapsed since the last dose of tetanus toxoid, diphtheria toxoid and/or pertussis containing vaccine.
Child: As a combination product with diphtheria, tetanus, inactivated poliomyelitis and HIB conjugate vaccine: 3 doses of 0.5 ml each, given at 1 mth intervals. Booster dose may be given at 18 mth-6 yr of age prior to school entry (3 yr after primary course).

Contraindications

Hypersensitivity to active substances and/or neomycin, polymyxin or formaldehyde.

Special Precautions

Continue immunisation with acellular pertussis vaccine even during episodes of fever, hypotonic-hyporesponsive episodes, persistent crying or screaming or severe local reactions have occurred after a preceding dose. Children with personal or family history of convulsions or epilepsy. Children with a local or general reaction to a whole-cell pertussis vaccine should complete their immunisation with acellular pertussis vaccine. If a seizure associated with fever occurs within 72 hr of immunisation or a child experiences encephalopathy or encephalitis within 7 days of immunisation, defer further immunisation until the condition is stable if no underlying cause is found and the child has not recovered completely within 24 hr.

Adverse Reactions

Local reactions at inj site, fever and irritability, may start a few hrs after inj and last for 1 or 2 days, possibly with inflammation and lymphangitis. Rare neurological reactions e.g. convulsions and encephalopathy. Hypersensitivity reactions may occur and anaphylaxis has been reported rarely.

Pregnancy Category (US FDA)

IM/Parenteral: C

Drug Interactions

Reduced immune response in patients who are also taking immunosuppressants.

Action

Description:
Mechanism of Action: Pertussis vaccine is used for active immunisation against pertussis.

Storage

Store at 2-8 °C, do not freeze and protect from light.

MIMS Class

Vaccines, Antisera & Immunologicals

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